| Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein. | retinoblastoma, |
| p28 expression resulted in an accumulation of hypophosphorylated retinoblastoma protein (pRb), tumor suppressor p53, and cyclin-dependent kinase (Cdk) inhibitor p21(Cip1). | retinoblastoma, |
| Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon. | colorectal, |
| PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor. | prostate, |
| BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. | breast, |
| Genistein induces the expression of tumor suppressor genes p21 (WAF1/CIP1/KIP1) and p16 (INK4a) with a concomitant decrease in cyclins in prostate cancer cells. | prostate, |
| Results show that that p21(Cip1) functions as a tumor suppressor in cervical carcinogenesis and that p21(Cip1) inactivation by HPV-16 E7 partially contributes to the contribution of E7 to cervical carcinogenesis. | cervical, |
| The water extract of the lettuce Lactuca sativa activated checkpoint kinase 2, induced the tumour suppressor p21, and downregulated the proto-oncogene cyclin D1 in HL-60 leukaemia cells and MCF-7 breast cancer cells | breast, |
| A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma. | esophageal, |
| LIF/p21 signaling cascade as a novel tumor suppressive-like pathway in melanoma, acting downstream of TGFbeta to regulate cell cycle arrest and cell death, further highlight new potential therapeutic strategies for the treatment of cutaneous melanoma | skin, |
| tumor suppressive function of HPCAL1 was dependent on p21 in hepatocellular carcinoma | liver, |
| Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma | cholangiocarcinoma, |
| A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. | None |
| p21(Cip1) nullizygosity increases the incidence of metastatic tumors in irradiated mice, suggestING that p21(Cip1) is haploinsufficient for tumor suppression and functions as an antimetastatic agent. | None |
| Tumor suppressor activity of RUNX3 is associated with its ability to induce p21 (WAF1/Cip10) expression. | None |
| The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. | None |
| P21(WAF1/CIP1) may be a tumor suppressor after all. | None |
| These data suggest that the ability of p21 to induce cell-cycle arrest may lead to tumor suppression in some types of cancer. | None |
| Data demonstrate that the long-term suppression of Plk1 increases the levels of cyclin-dependent kinase inhibitor p21(WAF1/CIP), which is partially induced by the elevated tumor suppressor p73 in p53-inactivated HeLa cells. | None |
| These data demonstrate that miR-K1 represses the expression of p21, a protein with known tumor suppressor functions, and suggest that this human herpesvirus 8 miRNA is likely to contribute to the oncogenic potential of this virus. | None |