| Results reveal a tumor suppressor role of p27 in chronic hepatocyte injury-induced liver tumorigenesis and, at the same time, the need to further study the mechanisms for tumor promotion by p27 inactivation. | liver, |
| MiR-221/222 can be regarded as a new family of oncogenes, directly targeting the tumor suppressor p27(Kip1), and their overexpression might be contribute to the oncogenesis and progression of prostate carcinoma through p27(Kip1) down-regulation | prostate, |
| Demonstration of a liver tumor suppressor role of p27 in a liver cancer resistant mouse strain. | liver, |
| p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma. | osteosarcoma, |
| deregulation of control mechanisms at G1/S transition by combination of high cyclin E levels in the absence of p27(Kip1) is sufficient to predispose mice to develop lymphoid malignancies and further support a role of p27(Kip1) as a tumor suppressor | None |
| Phosphorylation of p27 on Ser10 is an important event in the regulation of the tumor suppressor function of p27. | None |
| Equally a tumor suppressor and an additional predisposing system for tumorigenesis. | None |
| novel aspects of the p27(KIP1) protein, which displays genetically separable tumor suppressing and oncogenic functions. | None |
| results extend previous findings of CDKN1B mutations in patients with MEN1-related states and support the hypothesis of a tumor suppressor role for p27 in neuroendocrine cells | None |
| Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. | None |
| The p27 tumor suppressor gene CDKN1B acts as a disease modifier for the multiple endocrine neoplasia (MEN)1 syndrome associated with MEN1 germline mutations. | None |
| Structural prediction of the interaction of the tumor suppressor p27(KIP1) with cyclin A/CDK2 identifies a novel catalytically relevant determinant | None |
| p27kip1: An all-round tumor suppressor | None |
| Pleiotropic p27(Kip1), BCR-ABL and leukemic stem cell: the trio in concert. | leukemia, |
| MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. | liver, |
| The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. | prostate, |
| These data show that an oncogenic herpesvirus, as in the case of many cancers, can exploit the miRNA machinery for suppressing cell cycle regulatory molecules such as p27(Kip1) in the induction and progression of T-cell lymphomas. | lymphoma, |
| SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells. | leukemia, |
| 14-3-3epsilon functions as an oncogene in SGC7901 gastric cancer cells through involvement of cyclin E and p27kip1. | gastric, |
| In thyroid cancer cells, oncogene activation prevented TGF-beta/SMAD-dependent p27 repression, and CDK2/SMAD3 phosphorylation, leading to p65 NFkappaB upregulation which repressed BAX, induced cyclin D1 and promoted TGF-beta-dependent growth. | thyroid, |