| Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model. | pancreatic, |
| Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China. | lung, |
| [Expression of ubiquitin associated protein 1 gene and tumor-suppressor gene p16 in acute leukemia]. | leukemia, |
| ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice | osteosarcoma, |
| study presents a novel functional interaction of p16 and K-Ras. Re-expression of the tumor suppressor in pancreatic cancer cells restricted Ras oncoprotein activity, which resulted in loss or reduction of their transforming potential | pancreatic, |
| Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells. | pancreatic, |
| Novel frameshift mutation in the p16/INK4A tumor suppressor gene is described in canine breast cancer that alters expression from the p16/INK4A/p14ARF locus. | breast, |
| Studies indicate that an alternative splice variant of P16(INK4A), termed p12, is a tumor suppressive protein distinct from P16, and its genetic inactivation is associated with pancreatic carcinogenesis. | pancreatic, |
| Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. | cervical, |
| Radiation-induced double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation. | glioma, |
| Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. | glioma, |
| Controlled by the retinoblastoma gene product pRB, p16 acts as a tumor suppressor protein by inhibiting the G1-checkpoint regulatory cyclin-dependent kinases. | retinoblastoma, |
| Study provides clear evidence that p16 is a suppressor of the oncogenic ERK pathway and its effect is mediated via miR-21-5p inhibition in osteosarcoma cells. | osteosarcoma, |
| Altered microRNA Expression Profiles and Regulation of INK4A/CDKN2A Tumor Suppressor Genes in Canine Breast Cancer Models | breast, |
| The 5_-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding | skin, |
| Detecting abnormal methylation of tumor suppressor genes GSTP1, P16, RIZ1, and RASSF1A in hepatocellular carcinoma and its clinical significance | liver, |
| Data indicate that glioma tumor suppressor candidate region gene 2 product (GLTSCR2)-tumor suppressor protein p14ARF (ARF) binding was crucial for the nucleoplasmic translocation of ARF. | neoplasm,glioma, |
| Immunohistochemical Expression of the Tumor Suppressor Protein p16INK4a in Cervical Adenocarcinoma | cervical, |
| This study shows that H3.3K27M mutation and PDGF signaling act in concert to accelerate gliomagenesis in a genetic mouse model and identifies repression of p16 tumor suppressor as a target of H3.3K27M. | glioma, |
| The methylation of the p16 gene promoter could significantly reduce p16 expression, losing its tumor suppressor activity and promoting the development of cervical cancer. | cervical, |