| Concomitant loss of the Ink4a/Arf tumor suppressor locus accelerates tumor formation and metastasis, suggesting potential roles for the p16 and p19 tumor suppressors in this process. | None |
| Results allow the dissection of the protein-protein binding and CDK4 inhibition functions of P16, show that the difference between tumor suppressing and oncogenic functions of P16 and gankyrin, respectively, mainly resides in a single residue. | None |
| N-ethyl-N-nitrosourea (ENU)-induced meningiomatosis and meningioma in p16(INK4a)/p19(ARF) tumor suppressor gene-deficient mice. | None |
| Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor. | None |
| A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function. | None |
| Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest. | None |
| An important role for autophagy in tumor suppression via full-length ARF in both p53-dependent and p53-independent manners, depending on cellular context. | None |
| Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. | None |
| Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity. | None |
| this is the first report that experimentally links the tumour suppressor p16 to the process of lymphangiogenesis. | None |
| COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells. | None |
| Results show that p14ARF associates with Brca1, which may play a major role in tumor suppression. | None |
| These findings implicate MBD2 in transcriptional repression of the methylated p14(ARF) tumor suppressor gene and suggest that repression by MBD2 selectively affects a subset of methylated promoters. | None |
| RAF may induce cell proliferation through hypermethylation of tumor suppressor gene p16INK4A | None |
| The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. | None |
| CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. | None |
| Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice. | None |
| Increased senescence as mediated by the p16(INK4A) tumor suppressor has only a minor function as an intrinsic regulator of steady-state HSC ageing in vivo. | None |
| Results substantiate the critical role of CTCF in establishing and maintaining p16INK4A and other tumor suppressor genes in higher-order chromosomal domains through appropriate boundary formation. | None |
| Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. | None |