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Cancertype
Data suggest that tumor suppressor gene Cited2 is direct target of microRNA-182-5p; here, carcinogenic solvent trichloroethylene (TCE) up-regulates expression of microRNA-182-5p in liver; TCE-induced hepatocyte cell proliferation is mediated by microRNA-182-5p overexpression and down-regulation of Cited2 expression.
liver,
CITED2 is a direct effector of PPARgamma for tumor suppression.
None