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Cancertype
DLC1 might act as a congenital heart disease-associated gene in addition to its role as a tumor suppressor in cancer.
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Subsequent studies have demonstrated that DLC-1 is generally expressed in normal human tissues as well as in rats, while it always exists inactivated or even lost in many human cancers, which characterizes DLC-1 as a potential tumor suppressor. [review]
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DLC1: a tumor suppressor that regulates Rho signaling
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The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function
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these findings indicate cooperation between the SRC, ERK1/2, and AKT kinases to reduce DLC1 Rho-GAP and tumor suppressor activities in cancer cells, which can be reactivated by the kinase inhibitors.
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A tumor suppressor DLC1: The functions and signal pathways
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Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function
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