| This is the first report indicating YAP as a tumor suppressor, revealing its decreased expression in breast cancer as well as demonstrating the functional implications of YAP loss in several aspects of cancer signaling. | breast, |
| The existence of a proapoptotic autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia (PML) tumor suppressor gene, is shown. | leukemia, |
| YAP function as a tumor suppressor may alternatively be dysregulated by AKT phosphorylation at serine-127 and cytoplasmic sequestration, or by transcriptional repression by DeltaNp63, in different subsets of head and neck squamous cell carcinomas (HNSC... | HNSC, |
| YAP function as a tumor suppressor may alternatively be dysregulated by AKT phosphorylation at serine-127 and cytoplasmic sequestration, or by transcriptional repression by DeltaNp63, in different subsets of head and neck squamous cell carcinomas (HNSCCs). | HNSC, |
| YAP may act as a tumor suppressor in invasive breast carcinomas and it can also be used as a molecular marker for ER and PR negative breast tumors. | breast, |
| alphaE-catenin as a tumor suppressor that inhibits Yap1 activity and sequesters it in the cytoplasm. | None |
| YAP functions as a tumor suppressor that enhances apoptosis by modulating p53 during chemotherapy. | None |
| Studies indicate that yes-associated protein (YAP)-1 plays a dual role as oncogene and tumor suppressor gene in oncogenesis, depending on the specific tissue type involved. | None |
| Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner | None |
| Our findings demonstrate that circYAP1 functions as a tumor suppressor in GC cells by targeting the miR-367-5p/p27 (Kip1) axis and may provide a prognostic indicator of survival in GC patients.#This is the parental gene. | None |
| Dual role of YAP: oncoprotein and tumor suppressor | None |
| MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties. | liver, |
| miR-375 is an important regulator of YAP oncogene playing the role in hepatocellular carcinoma development. | liver, |
| Hippo pathway effector Yap is an ovarian cancer oncogene. | ovarian, |
| YAP is a candidate oncogene for esophageal squamous cell carcinoma. | esophageal, |
| The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene. | ovarian, |
| Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. | gastric, |
| Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation. | liver, |
| Wnt/beta-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. | colorectal, |
| these results implicate YAP as an oncogene whose expression is driven by aberrant Wnt/beta-catenin signaling in human colorectal carcinoma cells. | colorectal, |