| YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma. | pancreatic, |
| Results point to a potential oncogenic role for YAP in 11q22-amplified human cancers, and suggest that this signaling pathway regulates both cellular proliferation and apoptosis in mammalian epithelial cells. | None |
| Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. | None |
| Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. | None |
| LATS1 inactivates YAP oncogenic function by suppressing its transcription regulation of cellular genes via sequestration of YAP in the cytoplasm after phosphorylation of YAP. | None |
| Tumor suppressor LATS1 is a negative regulator of oncogene YAP. | None |
| findings suggest that activation of the Hippo signaling pathway may occur through YAP as part of cell proliferation in normal tissue homeostasis and also might be a frequently activated oncogenic pathway in 3 common malignant tumor types. | None |
| The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. | None |
| Data suggest that the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program. | None |
| AXL is a mediator of YAP-dependent oncogenic activities | None |
| AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. | None |
| PTPN14 interacts with and negatively regulates the oncogenic function of YAP. | None |
| Vgll1 interacts with TEAD4 in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1 has the potential to promote cancer progression. | None |
| Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. | None |
| Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. | None |
| Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. | None |
| YAP1 oncogene and its eight isoforms. | None |
| yes-associated protein 1 (YAP; also known as YAP1)--a protein known for its powerful growth-inducing and oncogenic properties--has an unexpected growth-suppressive function, restricting Wnt signals during intestinal regeneration | None |
| F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene | None |
| Data demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation. | None |