| Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. | leukemia,pediatric, |
| Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. | colorectal, |
| In a mouse model of advanced atherosclerosis, mutation of the phagocytic Mertk receptor (c-mer proto-oncogene tyrosine kinase) promotes the accumulation of apoptotic cells and the formation of necrotic plaques | None |
| Data indicate that AAV2-VMD2-c-mer proto-oncogene protein (hMERTK) provided up to 6.5 months photoreceptor rescue in the RCS rat, and also had a major protective effect in Mertk-null mice. | None |
| Data show that activated AMP-activated protein kinase (AMPK) limits retinal pigment epithelial cells (RPE) phagocytic activity by abolishing retinal photoreceptor cell outer segment (POS)-induced activation of c-mer proto-oncogene tyrosine kinase (MerTK). | None |
| Signaling through the Mer proto-oncogene tyrosine kinase (MerTK) receptor in cultured macrophages and in sterile inflammation in vivo promotes specialized proresolving mediator (SPM) biosynthesis by a mechanism involving an increase in the cytoplasmic:nuclear ratio of a key SPM biosynthetic enzyme, 5-lipoxygenase. | None |
| Blockade of MER proto-oncogene tyrosine kinase (MerTK) results in accumulation of apoptotic cells within tumors and triggers type I interferon response. Treatment of tumor-bearing mice with anti-MerTK antibody stimulates T cell activation and synergizes with anti-PD-1 or anti-PD-L1 therapy. Abolishing cGAMP production, depleting extracellular ATP, or inactivating ATP-gated P2X7R channel compromises anti-MerTK blockade. | None |