Showing 1-4 of 4 items.

Sentence	Cancertype
CTCF and BORIS suppressed breast cancer growth; findings provide further evidence that CTCF behaves as a tumor suppressor, and show BORIS has a similar growth inhibitory effect in vitro and in vivo	breast,
Data shows that T204fs, a frameshift mutation in CTCF gene is frequent in endometrial neoplasms with microsatellite istability. Also, The spectrum and pattern of mutations observed is consistent with CTCF acting as a haploinsufficient tumor suppressor.	neoplasm,endometrial,
observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific change of function rather than complete loss of function	None
Results substantiate the critical role of CTCF in establishing and maintaining p16INK4A and other tumor suppressor genes in higher-order chromosomal domains through appropriate boundary formation.	None