| CHL1 gene acts as a tumor suppressor in human neuroblastoma | neuroblastoma, |
| Results identified a new tumor suppressor, CHL1, located at 3p26 which was frequently deleted in esophageal squamous cells carcinoma (ESCC). Reduced expression of CHL1 correlated with poor differentiation, increased invasion, lymph-node metastasis, advanced tumor stage, and decreased overall survival. Further data support CHL1 as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities. | esophageal, |
| The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination. | None |
| MicroRNA-590 promotes cervical cancer cell growth and invasion by targeting CHL1. | cervical, |
| our findings suggest that miR-590-5p acts as an oncogene by targeting the CHL1 gene and promotes cervical cancer proliferation | cervical, |