| CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. | breast, |
| study demonstrates that the Src/Stat3 and C/EBP signaling pathways positively regulate the expression of the Jab1 oncogene; results show that Stat3 and LAP2 (C/EBP-beta2) are the two major transcription factors that contribute to Jab1 overexpression that leads to increased proliferation of breast cancer cells | breast, |
| The oncoproteins are all associated with the abovementioned key oncogenic pathways, may play critical roles in the putative oncogenic function of JAB1 in prostate cancer. | prostate, |
| Results found JAB1 expression increased in triple-negative breast cancer (TNBC) cells and associated with poor prognosis. Also, JAB1 expression was regulated by miR-17 in TNBC cells. miR-17 suppressed JAB1_s oncogenic function, leading to tumor growth inhibition and sensitizing TNBC cells to chemotherapy. | breast, |
| regulation of p27 via modulation of the Jab1 subcomplex is a novel mechanism whereby Bcr-Abl oncogenic signals accelerate abnormal cell proliferation. | None |
| highlight recent advances in studies of the oncogenic role of Jab1/CSN5 in NPC and its potential as a therapeutic target for this cancer | None |
| The oncogenic effects of CSN5 on OS cells were EGFR dependent. | None |