| results suggest that PTENP1 functions as a novel tumor suppressor in gastric cancer and its suppressive ability may be involved in the modulation of PTEN | gastric, |
| PTENP1 is a highly homologous processed pseudogene of the tumor suppressor gene PTEN (MIM 601728) that itself exerts a tumor suppressive function by acting as a decoy for PTEN-targeting miRNAs . As a model for the protein-coding-independent role of RNAs, we describe the functional relationship between the mRNAs produced by the PTEN tumour suppressor gene and its pseudogene PTENP1 and the critical consequences of this interaction. We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. | None |
| In this review, author summarized the gene as tumor suppressor in table 2. | None |
| we revealed a tumor suppressive role of PTENP1 as ceRNA in GC and pinpointed the specific miRNAs decoyed by PTENP1, highlighting the emerging roles of ceRNAs in the biological regulation of GC cells and their possible clinical significance. | None |