| WIF1 may be a tumor suppressor, specifically in nonfunctioning pituitary tumors, and that the Wnt pathways are important in pituitary tumorigenesis. | pituitary, |
| analyzed 5 osteosarcoma cell lines in a high-throughput screen for epigenetically silenced tumor suppressor genes and identified Wnt inhibitory factor 1 (WIF1) as a candidate tumor suppressor gene | osteosarcoma, |
| the WIF-1 is downregulated by promoter methylation and functions as a tumor suppressor gene by inducing apoptosis in human renal cell carcinoma cells. | kidney, |
| WIF-1 is downregulated and functions as a tumor suppressor by antagonizing Wnt/beta-catenin signaling in neuroblastoma. | neuroblastoma, |
| MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1. | colorectal,liver, |
| Thus, WIF1 functions as a tumor suppressor for both NPC and ESCC through suppressing the Wnt-signaling pathway, but is frequently silenced by epigenetic mechanism in a tumor-specific way. | None |