| Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. | leukemia, |
| Five percent of women with uterine serous carcinoma have germline mutations the tumor suppressor genes BRCA1, CHEK2, and TP53. | uterine, |
| Chromosomal instability is induced by overexpression of the oncogene AURKA or by loss of the tumour suppressor gene CHK2, a genetic constitution found in colorectal cancers. | colorectal, |
| Results indicate that CHEK2 possesses non-cell-autonomous tumor suppressor functions, and present the Chk2 protein as an important mediator in the functional interplay between breast carcinomas and their stromal fibroblasts through repressing the expression/secretion of SDF-1 and IL-6. | breast, |
| Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. | None |
| Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor. | None |
| Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. | None |
| DNA damage tumor suppressor genes and genomic instability. | None |
| p53-independent role for Chk2 in p21 induction and senescence that may contribute to tumor suppression | None |
| the combination of hypoxia and reoxygenation results in a G2 checkpoint response that is dependent on the tumor suppressor Chk2 and that this checkpoint response is essential for tumor cell adaptation to changes | None |
| Fusion of the tumor-suppressor gene CHEK2 and the gene for the regulatory subunit B of protein phosphatase 2 PPP2R2A in childhood teratoma. | None |
| Mutations L303X & 1100delC cause a premature termination codon preventing CHEK2 & P-Thr68 CHEK2 protein expression. CHEK2 & p53 operate in the same tumor suppressor pathway.A main CHEK2 oncogenic function involves p53-mediated G1 cell-cycle arrest. | None |
| These data suggest that Chk2 suppresses the oncogenic potential of DNA damage arising during S and G2 phases of the cell cycle. | None |
| Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta. | None |
| our results further revealed that expression of tumor suppressor gene, checkpoint kinase 2, was negatively regulated by miR-191 | None |
| CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly | None |
| the combination of hypoxia and reoxygenation results in a G2 checkpoint response that is dependent on the tumor suppressor Chk2 and that this checkpoint response is essential for tumor cell adaptation to changes | None |