| KLF6 gene is a direct target of miR-181a and miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6. | gastric, |
| miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6. | gastric, |
| KLF6 is a putative tumor suppressor gene involved in osteosarcoma which can be used as a new therapeutic target and an important marker for early diagnosis and postoperative monitoring. | osteosarcoma, |
| KLF6 protein is downregulated in human cutaneous malignant melanoma lesions compared with healthy skin tissue. KLF6 may be involved in tumour progression and may be a tumour suppressor and prognostic marker | skin, |
| H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach | sarcoma, |
| Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the expression of mesenchymal markers, such as snail, slug, and vimentin. Our study is the first to provide demonstrate that KLF6 functions as a tumor suppressor gene and prevents the metastasis of oral cancer cells. | oral |
| Decreased expression of KLF6-SV2 may be associated with the occurrence and development of colorectal cancer. KLF6-SV2 plays a role as tumor suppressor by efficiently blocking cell proliferation, arresting cell cycle and inducing apoptosis in colorectal cancer, which may be related to increased expression of p21 and Bax. | colorectal, |
| Our results provide the first evidence of functional tumor suppression by KFL6, and its loss may contribute to glial tumor progression. | None |
| Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein. | None |
| Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. | None |
| examination of role as potential tumor suppressor gene product | None |
| Deregulation of KLF6 stability may alter its tumor suppressor function and/or the response of tumors to chemotherapeutics | None |
| Our results demonstrate the induction of the tumor suppressor KLF6 following PKC activation and its importance for PMA-mediated cancer cell growth arrest. | None |
| Nucleo-cytoplasmic localization domains regulate Kr??ppel-like factor 6 (KLF6) protein stability and tumor suppressor function. | None |
| A transcriptional network involving the tumor suppressors Kruppel-like factor 6 and forkhead box O1 negatively regulate activated EGFR signaling in both cell culture and in vivo cancer models | None |
| GSK3beta phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21. | None |
| KLF6 acts as a tumor suppressor in CMM cells and miR-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR inactivation and p21 upregulation. | None |
| Increased expression of the oncogenic KLF6-SV1 transcript in human glioblastoma. | glioblastoma, |
| Overexpression of KLF6 markedly attenuated the oncogenic effect of miR-543 overexpression in clear cell renal cell carcinoma. | kidney, |
| The Kruppel-like transcription factor family has an essential role in the regulation of many processes including cell proliferation, differentiation, signal transduction, oncogenesis, and cell death. | None |