| Data indicate CUX1 as a conserved, haploinsufficient tumor suppressor frequently deleted in myeloid neoplasms. | neoplasm, |
| mediates proteolysis of the tumor suppressor p200 CUX1, which promotes cell proliferation and inhibits cell differentiation in acute promyelocytic leukemia | leukemia, |
| Cux1 is a tumor suppressor and inactivating CUX1 mutations promote tumorigenesis. | None |
| The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters | None |
| The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11). | lymphoma,leukemia, |
| we identified a novel CUX1-FGFR1 fusion oncogene in a patient with the 8p11 myeloproliferative syndrome and demonstrated its transforming potential in the Ba/F3 cell line. | None |