| our study suggested that DDX3 prevents generation of cancer stem cells through epigenetically regulating a subset of tumor-suppressive miRNAs expressions, which strengthens tumor suppressor role of DDX3 in hepatocellular carcinoma. | liver, |
| DDX3 suppresses tumor growth and transcriptionally activates the p21 promoter, and is inactivated through down-regulation of gene expression or alteration of subcellular localization in tumor cells; DDX3 might be a candidate tumor suppressor. | None |
| Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein. | None |
| DDX3 may play an oncogenic role to promote tumor growth and invasion in colon cancer cells | colorectal, |