| Testing the role of Egr1 in a two-step skin carcinogenesis study revealed an accelerated development of skin tumors in Egr1-null mice. Studies reveal a new role for Egr1 as an in vivo tumor suppressor. | skin, |
| Leukemia suppressor function of Egr-1 is dependent on transforming oncogene. | leukemia, |
| Findings demonstrate that EGR1 is a key player in the transcriptional control of miR-20b, and miR-20b may in turn function as an oncogene by contributing to breast tumorigenesis via tumor suppressor targeting. | breast, |
| Sulforaphene inhibits triple negative breast cancer through activating tumor suppressor Egr1 | breast, |
| These results suggest that frameshift mutations of EGR1 and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer. | gastric,colorectal, |
| EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma | sarcoma, |
| reveal a novel role for protein phosphatase 1 inhibitor in the regulation of the tumor suppressor gene EGR1 via activation of the MEK-ERK MAPK pathway | None |
| Data show that miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types. | None |
| ATF3 and EGR1 are involved in the beginning of inflammatory processes. Whether these two transcription factors act as tumour suppressors or promoters is context dependent and warrants analysis in further studies | None |
| Transcription factor early growth response-1 plays an oncogenic role in salivary gland pleomorphic adenoma. | None |