Showing 21-26 of 26 items.

Sentence	Cancertype
EIF4E is a key regulator of protein synthesis, and an oncogene; its expression and activity are often elevated in both hematological malignancies and solid tumors	None
model that links the pro-neoplastic function of eIF4F to its ability to disable oncogene-activated tumor surveillance programs	None
Findings provide new evidence that PRMT5 plays an important role in CRC pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E and FGFR3.	None
Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.	None
Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA.	None
Our studies also suggest that nuclear entry is important for the prooncogenic activity of eIF4E, at least in this context. These findings position nuclear trafficking of eIF4E as a critical step in its regulation and position the importin 8-eIF4E complex as a novel therapeutic target.	None