| Study found that overexpression of ESE-1 suppressed tumorigenicity in a xenograft mouse, and repressed anchorage-independent growth and migration/invasion in human colon cancer cells. ESE-1 localized abundantly in the nucleus, and internal deletion of nuclear localization sequence 2 reduced nuclear ESE-1 particularly the three lysine residues (318-320). These data suggest that ESE-1 is a tumor suppressor in colon cancer. | colorectal, |
| ELF3 is a frequently mutated tumor suppressor gene of periampullary tumors. | None |
| ELF3 is an oncogene in lung adenocarcinoma. ELF3 signaling networks are highly tissue-specific, accounting for its conflicting functions across epithelial cancers. | lung, |