| These results support a role for BHD as a tumor suppressor gene that predisposes to the development of renal tumors when both copies are inactivated. | kidney, |
| FLCN is shown as a general tumour suppressor in the kidney. | kidney, |
| Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn | kidney, |
| Based on the phenotypes of our preclinical models, the FLCN H255Y mutant protein has lost it tumour suppressive function leading to the clinical manifestations of BHD, whereas the FLCN K508R mutant protein may have a dominant negative effect on the function of wild-type FLCN in regulating kidney cell proliferation and, therefore, act as an oncoprotein | kidney, |
| Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer | kidney, |
| potential role of BHD as a tumor suppressor gene (review) | None |
| The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance. | None |
| plays role in tumor suppression and inhibition on rapamycin pathway | None |
| FLCN tumor suppressor gene inactivation induces TFE3 transcriptional activity by increasing its nuclear localization | None |
| Loss of the Birt-Hogg-Dub?® tumor suppressor results in apoptotic resistance due to aberrant TGF??-mediated transcription. | None |
| FLCN mutations throughout the coding sequence, and suggest that multiple protein domains contribute to folliculin stability and tumor suppressor activity. | None |
| Findings suggest that aspects of folliculin tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA signalling. | None |
| FLCN functions as a tumor suppressor by negatively regulating rRNA synthesis. | None |
| These findings identify novel pathways and targets linked to folliculin tumour suppressor activity. | None |
| Tumor suppression function of FLCN may be linked to its impact on the cell cycle. | None |
| Folliculin - A tumor suppressor at the intersection of metabolic signaling and membrane traffic | None |
| The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue | None |
| AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR | None |