| This study indicates that autophagy has an anticancer role in clear-cell renal cell carcinoma tumorigenesis, and suggests that constitutive autophagic degradation of HIF2alpha is a novel tumor suppression mechanism. | kidney, |
| Peroxisome abundance is reduced in von Hippel-Lindau (Vhl) tumor suppressor -deficient human clear cell renal cell carcinomas with high HIF-2alpha levels. | kidney, |
| HIF2alpha is linked to tumor suppression in neuroblastoma. | neuroblastoma, |
| lncRNA HIF2PUT may act as a tumour suppressor in osteosarcoma | osteosarcoma, |
| Results confirm that HIF-2alpha is tumor suppressive, and suggest that HIF-1alpha may also be tumor suppressive. | None |
| These results support a direct oncogenic role for HIF2A in human neoplasia and strengthen the link between hypoxic pathways and pheochromocytomas and paragangliomas. | PCPG,glioma, |
| Results suggested that the oncogenic transcription factor HIF-2alpha stabilized VHL disease suppressor B-Myb, which is also a transcription factor, by physical interaction. Some B-Myb-dependent gene expression was similarly affected by B-Myb or HIF-2alpha knockdown, suggesting that stabilization of B-Myb by HIF-2alpha may play a role in specific gene expressions. | None |