| ErbB4 signaling is growth inhibitory and may be coupled to tumor suppression in prostate cells | prostate, |
| phosphorylation of ErbB4 tyrosine 1056 is critical for coupling ErbB4 to prostate tumor suppression | prostate, |
| Pregnancy and extended lactation durations have been correlated with reduced risk of breast cancer, and the role of ErbB4 in tumor suppression may therefore be linked with its role in lactation. | breast, |
| results suggest that ErbB4 is not a potent, highly penetrant tumor suppressor, nor is it a factor in Neu-mediated tumorigenesis in this model | None |
| These data suggest that ErbB4 behaves as a mammary tumor suppressor and that loss of ErbB4 coupling to growth arrest may be an important event in mammary tumorigenesis. | None |
| cycle-dependent degradation of s80(HER4) limits its growth-inhibitory action, and stabilization of s80(HER4) enhances tumor suppression, thus providing a link between HER4-mediated growth inhibition and cell cycle control | None |
| HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. | skin, |
| Results further emphasize the role of HER4 as an important oncogene in malignant melanoma. | skin, |
| Absence of EGFR, ERBB2 and ERBB4 mutation homologous to the oncogenic ERBB3 Val-104 mutation in colorectal cancers. | colorectal, |
| identifying neuregulin 1 and its cognate receptor ERBB4 [epidermal growth factor receptor (EGFR) family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4] as a major receptor complex that activates YAP activity | leukemia, |
| the HER4 G1109C mutation is an activating oncogenic mutation with a transformational ability and that afatinib was effective against an HER4 G1109C-mutated HNSCC cell line by inhibiting the HER4 signal, both in vitro and in vivo. | HNSC, |
| There are isoform-specific roles of ERBB4 during puberty and early pregnancy. CYT-1 ERBB4a has oncogenic properties. | None |
| findings indicate that feedback mechanisms are key switches determining oncogenic potentials of ErbB receptor kinases | None |