| Data show that activated proto-oncogene protein Akt (AKT) directly phosphorylates Fas associated factor 1 (FAF1) reduces FAF1 at the plasma membrane and results in an increase in TGF-beta type II receptor (TbetaRII) at the cell surface. | None |
| Data suggest activation of PAR2 via FVIIA/TF signaling activates PI3K/AKT signaling, inactivates GSK3b signaling, leads to accumulation of beta-catenin, and promotes tumor cell migration/invasion. (PAR2 = protease-activated receptor 2; FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin; PI3K = phosphatidylinositol 3-kinase; AKT = proto-oncogene protein c-akt; GSK3b = glycogen synthase kinase 3 beta) | None |
| REVIEW: Oncogenic Roles of the PI3K/AKT/mTOR Axis | None |
| Data suggest that PLSCR1 is involved in viral entry; here, herpes simplex viruses activate PLSCR1 and up-regulate flipping of phosphatidylserines and AKT to outside of plasma membrane shortly following HSV-1 or HSV-2 exposure. (PLSCR1 = phospholipid scramblase 1; AKT = proto-oncogene c-Akt) | None |
| Data suggest that malignant transformation of bronchial epithelial cells caused by cigarette smoke involves up-regulation of HIF1A and MIRN21 expression, down-regulation of PTEN, and activation of Akt/NFkappaB signaling. (HIF1A = hypoxia inducible factor 1 alpha subunit; MIRN21 = microRNA 21; PTEN = phosphatase and tensin homolog protein; Akt = proto-oncogene c-Akt) | None |
| Results suggest that the enhanced akt proto-oncogene rotein AKT phosphorylation (pAKT) in circulating B cells may be useful for the discrimination of immunologic deficiency syndromes APDS1, APDS2, and APDS-L from other antibody deficiencies. | None |
| An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene Myc in Drosophila neurons. | None |
| Data show that oncogenic phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (PI3K)-proto-oncogene protein Akt (AKT)-activated epidermis exhibits a growth disadvantage even though its cells are more proliferative. | None |
| Data show that Y-box binding protein-1 (YBX1) promoted tumorigenesis and progression in spinal chordoma via the epidermal growth factor receptor (EGFR)/proto-oncogene proteins c-akt (AKT) pathway. | None |
| High activity of HDAC3 stabilizes c-Myc (v-myc myelocytomatosis viral oncogene homolog) protein by preferential deacetylation of cMyc at the K323 site, which contributes to the low pyruvate levels. | None |
| Results suggest that tenascin-C (TNC) may enhance the cancer stem-like properties and promote epithelial-to-mesenchymal transition (EMT)-like changes via the proto-oncogene proteins c-akt (Akt)/hypoxia-inducible factor 1, alpha subunit (HIF1alpha) axis. | None |
| Tumor necrosis factor receptor-associated factor 6 (TRAF6)-mediated proto-oncogene protein Akt (AKT) ubiquitination and subsequent phosphorylation played an essential role in the control of tumor cell malignant behavior. | None |
| The the expression of NANOG, SOX2, Kruppel-like factor 4 (KLF4), and proto-oncogene c-Myc was also increased by cytoplasmic dsRNA. | None |
| This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets. | None |
| The AKT1 proto-oncogene maps to human chromosome 14, band q32. | None |
| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. | None |
| Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. | None |
| The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. | None |