| These data illustrate that chromate induces both survival signaling and an inflammatory response in the lung, which may contribute to early oncogenesis. | lung, |
| Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells. | lymphoma, |
| Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas. | meningiomas,esophageal,prostate,laryngeal, |
| Overexpression of APPL1 protein in the liver of db/db obese mice suppressed the interaction between Proto-Oncogene Proteins c-akt and TRB3 protein. | liver, |
| The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. | endometrial, |
| AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. | bladder, |
| These results established a novel pathway that consists of proto-oncogene c-Akt, COX-2 and Mcl-1 for acquired apoptosis resistance in lung cancer cells. | lung, |
| Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. | breast, |
| CNK1 promotes oncogenic signalling through Akt in breast cancer cell lines and tumours. | breast, |
| Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations. | skin, |
| The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling. | lymphoma, |
| Expression of pERK and pAKT in pediatric high grade astrocytomas: correlation with YKL40 and prognostic significance. | pediatric,astrocytomas, |
| AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways. | neuroblastoma,liver,thymoma, |
| Alteration in methylation pattern of oncogene Akt1 promoter region in bladder cancer. | bladder, |
| Akt mediated Bmi1 phosphorylation, enhancing its oncogenic potential in an Ink4a/Arf-independent manner, affecting genome stability and prostate tumorigenesis. | prostate, |
| The viral oncogene Np9 acts as a critical molecular switch for co-activating beta-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. | leukemia, |
| A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways. | meningiomas, |
| Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. | meningiomas, |
| Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. | breast, |
| These results imply that, in glioblastoma cells, constitutive Akt signaling drives RIO kinase overexpression, which creates a feedforward loop that promotes and maintains oncogenic Akt activity through stimulation of mTor signaling | glioblastoma, |