| Data show that cytoplasmic cyclin-dependent kinase inhibitor p27 is preferentially observed in primary non-small cell lung cancer (NSCLC) with activated proto-oncogene proteins c-akt1 and predicts poor survival. | lung, |
| Mutant AKT1-E17K is oncogenic in lung epithelial cells. | lung, |
| PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway. | thyroid, |
| Data show that hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) is activated via an proto-oncogene protein Akt/mTOR protein signaling pathway in LCC2 and LCC9 breast cancer cells. | breast, |
| NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling. | endometrial, |
| Findings indicate inositol polyphosphate 5-phosphatase PIPP (INPP5J) as a suppressor of oncogenic phosphoinositide 3-kinase (PI3K)/AKT signaling in breast cancer. | breast, |
| Data show that interleukin-8 (IL8) was a direct target of microRNA miR-203, and reduced miR-203 promoted nasopharyngeal carcinoma (NPC) cell radioresistance by activating IL8/AKT (akt proto-oncogene protein) signaling. | nasopharyngeal,laryngeal, |
| These results suggest that Akt1 functions as a critical oncogene in human oral squamous cell carcinoma | oral |
| Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro. | gastric, |
| Data show that rapamycin-insensitive companion of mTOR protein (RICTOR) plays a central role in phosphatidylinositol 3-kinase (PI3K)/proto-oncogene protein c-akt (AKT) pathway in melanocytes and its deregulation could be involved in melanoma development. | skin, |
| Data indicate the role of tropomyosin-related kinase-B (TrkB) in activation of the interleukin-6/Janus kinase 2/STAT3 transcription factor and PI3 kinase/c-AKT proto-oncogene protein pathway in breast cancer. | breast, |
| Data show that dihydrotestosterone may affect ovarian follicular maturation by altering granulosa cell proliferation through the regulation of PPAR gamma (PPARgamma) dependent PTEN phosphohydrolase (PTEN)/akt proto-Oncogene protein (p-Akt) expression. | ovarian, |
| results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT, ERK, and Wnt | pancreatic, |
| Data suggest that claudin-18 suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of pyruvate dehydrogenase kinase isoform 1 (PDK1) and proto-oncogene protein c-akt (Akt). | lung, |
| Data indicate that proto-oncogene c-Akt (AKT) is important in cell cycle regulation in the control of chemosensitivity in ovarian cancer cells (OVCAs) and suggest an alternate regulatory pathway for the development of rationale therapy for cisplatin-resistant ovarian cancer. | ovarian, |
| Data suggest that activity of neuronal enzymes Akt1 and p38Mapk can be modulated by dietary factors; here, subchronic administration of ascorbic acid (a common antioxidant, antidepressant dietary supplement) at 1 mg/kg increases Akt1 phosphorylation in cerebral cortex of mice and decreases hippocampal p38Mapk phosphorylation. (Akt1 = thymoma viral proto-oncogene 1; p38Mapk = p38 MAP kinase) | thymoma, |
| Data show that knockdown of ubiquitin specific peptidase 39 (USP39), a direct target of microRNA microRNA-133a, induced cell apoptosis through inhibition of proto-oncogene proteins c-akt (AKT) signaling pathway in pancreatic cancer (PC) cells. | pancreatic, |
| High AKT1 expression is associated with oncogenicity and chemoresistance in hepatocellular carcinoma. | liver, |
| Activated glucocorticoid receptor induced phosphorylation of v-AKT Murine Thymoma Viral Oncogene Homologue (AKT) kinase, which in turn phosphorylated and promoted nuclear translocation of G3BP1. The nuclear G3BP1 bound to the G3BP1 consensus sequence located on primary miR-15b~16-2 and miR-23a~27a~24-2 to inhibit their maturation. | thymoma, |
| these results demonstrate that the oncogenic signal transducer and activator of transcription 5/Akt pathway is a cellular target for indole-3-carbinol in chronic myeloid leukemia cells. Thus, this clinically tested natural compound can be a potential candidate in the treatment of chronic myeloid leukemia following confirmation with clinical studies | leukemia, |