| Data suggest that LYAR induces proliferation and promotes survival of neuroblastoma cells by repressing the expression of oxidative stress genes such as CHAC1 and suppressing oxidative stress, and identify LYAR as a novel co-factor in N-Myc oncogenesis. | neuroblastoma, |
| Data show that LINC00963 (MetaLnc9) interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in non-small cell lung cancer (NSCLC) cells, leading to activation of the oncogenic AKT/mTOR signaling pathway. | lung, |
| This study revealed that ionizing radiation-induced epithelial-mesenchymal transition (EMT) as well as migration and invasion of glioma cells are mediated by cathepsin L through the proto-oncogene proteins c-akt (Akt)/glycogen synthase kinase-3beta (GSK-3beta)/EMT-related transcription factor snail and homeobox protein cut-like1 (CUX1) pathways. | glioma, |
| Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. | gastric, |
| Mechanistic investigations showed that Rab11-FIP2 interacted with the glycolytic kinase PGK1 and promoted its ubiquitination in NSCLC cells, leading to inactivation of the oncogenic AKT/mTOR signaling pathway. | lung, |
| H2O2 induces oxidative stress to breast cancer tumor cell line MCF-7 in a dose dependent manner. Over-expression of p110alpha protein restores pro-survival effects against H2O2 induced apoptosis and increase phosphorylated proto-oncogene proteins c-akt levels. | breast, |
| The overexpression of myocardial infarction associated transcript (MIAT) in melanoma promotes cell proliferation, cell invasion and migration. MIAT significantly upregulates the phosphorylation of phosphatidylinositol 3-kinases and proto-oncogene proteins c-akt and promotes cMyc and cyclin D1 protein expression. | skin, |
| Stem cells features and aberrant metabolic reprogramming of esophageal cancer stem cells (CSC) depend on the heat shock 27 kDa protein (Hsp27)-proto-oncogene protein Akt (AKT)-HXK2 hexokinase 2 (HK2) pathway. | esophageal, |
| MIIP suppresses oncogenic AKT-mTOR signaling in prostate cancer by facilitating PP1-mediated AKT dephosphorylation. | prostate, |
| Data indicate a mechanism of USP46 regulation in renal cell carcinoma (RCC), and that USP46 is a tumor suppressor in RCC via proto-oncogene protein Akt (AKT) signaling pathway inactivation. | kidney, |
| A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer. | breast, |
| Rejection antigen peptides on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes: derivation from the normally untranslated 5 region of the c-akt proto-oncogene activated by long terminal repeat. | leukemia, |
| Identification of a unique antigen peptide pRL1 on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene. | leukemia, |
| The Akt proto-oncogene links Ras to Pak and cell survival signals. | None |
| Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT). | None |
| The v-Crk oncogene enhances cell survival and induces activation of protein kinase B/Akt. | None |
| AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. | None |
| Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. | None |
| akt has roles in glucose metabolism, DNA synthesis, and oncogenic activity | None |
| Gas6 sustains fetal oligodendrocyte viability by receptor activation and downstream signaling via the phosphatidylinositol 3-kinase-dependent/ proto-oncogene protein akt pathway. | None |