| Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells. | None |
| 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. | None |
| Estradiol 17beta increased Akt proto-oncogene expression in the CA1 hippocampal region in both young and aged female rats. | None |
| Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. | None |
| these data demonstrates for the first time that JNK2a can regulate the transcriptional activity of STAT3 by phosphorylating the Ser727 residue, thereby regulating the expression of oncogenic genes, such as c-Myc. | None |
| data indicate that serpinE2 is up-regulated by oncogenic activation of Ras, BRAF and MEK1 and contributes to pro-neoplastic actions of ERK signaling in intestinal epithelial cells. | None |
| Activation of cloned dopamine D2 receptors in cerebral cortex leads to phosphorylation of proto-oncogene protein c-Akt and glycogen synthase kinase 3beta. | None |
| Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival. | None |
| TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. | None |
| FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide. | None |
| Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation. | None |
| The results showed that bradykinin stimulates Toll-like receptor 2 transcription and translation by activation of protein kinase C as well as proto-oncogene protein AKT. | None |
| Results suggest that oncogenic co-operation between HBx and Akt may be important for cell proliferation, abrogation of apoptosis and tumorigenic transformation of cells. | None |
| Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells. | None |
| Data suggest that AGPAT2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt and PPARgamma signaling in early stage of adipogenesis. | None |
| Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations. | None |
| What is the mechanism of serotonin-induced insulin resistance? Data suggest that activation of Akt (proto-oncogene protein c-akt) is involved in reducing adverse effects of serotonin by stabilizing IRS-1 in low density microsomes in adipocytes. | None |
| Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110alpha/PIK3CA but not by HER2 or mutant AKT1. | None |
| The AKT1 somatic mutants are constitutively active, leading to oncogenic signaling. | None |
| Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers. | None |