| Data show that significantly better overall survival was observed in patients with coexistence of high epidermal growth factor receptor (EGFR) expression and low p-Akt proto-oncogene protein expression. | None |
| A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors. | None |
| Pygo2 is a common node downstream of oncogenic Wnt and Akt signaling pathways. | None |
| Data indicate a link between proto-oncogene protein c-akt (AKT) mediated glycolytic metabolism and autophagy in the activated macrophages. | None |
| O-GlcNAcylation enhanced oncogenic phenotypes possibly partially involving PI3K/Akt signaling pathway | None |
| Data show that tumors with proto-oncogene protein c-akt (AKT1 E17K) mutations are rational therapeutic targets for AKT inhibitors. | None |
| Data suggest that primary cancer, hypoxic microenvironment generates positive feedback loops which hyperactivate proto-oncogene protein AKT, forming extreme robustness that forcing cancer cells to migrate to the distant site. | None |
| Data show that downregulating proto-oncogene protein Akt (p-Akt) by inhibiting PP2A inhibitor SET-mediated protein phosphatase 2A (PP2A) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment. | None |
| Oncogenic activation of the AKT-mTOR pathway promotes immune escape by driving expression of PD-L1. | None |
| Data show that musclin (Ostn) production is stimulated by Ca2+-dependent proto-oncogene protein c-Akt (Akt) phosphorylation. | None |
| Data show one single nucleotide polymorphism (SNP) in Fox transcription factor FOXO3 (FOXO3) was significantly associated with longevity, and the six SNPs in proto-oncogene protein AKT1 (AKT1) gene and in IGF-2 Receptor (IGF-2R) gene are not. | None |
| Data suggest that a dietary component/supplement, L-carnitine, protects hepatocytes against oxidative stress/cell damage (induced here by hydrogen peroxide) through AKT- (proto-oncogene protein c-akt)-mediated activation of NRF2 (nuclear factor [erythroid-derived 2]-like 2 protein) signaling pathway. | None |
| Data suggest that phosphorylated Ser473-Akt akt proto-oncogene protein may be a potential player in the major zygotic genome activation (ZGA) of 2-cell embryos. | None |
| Repurposing the PDE4 inhibitor roflumilast for treatment of B-cell malignancies is safe, suppresses the oncogenic PI3K/AKT kinases, and may be clinically active | None |
| Data indicate that overexpression of nitric oxide synthase 1 adaptor protein short form (CAPON-S) led to the inactivation of the proto-oncogene protein Akt (Akt) signaling pathway. | None |
| Data suggest a role for akt proto-oncogene protein (Akt) pathway in the pathogenesis of rheumatoid arthritis (RA). | None |
| Data show that spleen tyrosine kinase (SYK) and proto-oncogene protein c-akt (AKT1) proteins were increased in the cytoplasm of the cells forming Mallory-Denk bodies. | None |
| Findings suggest an important role for effector-like memory CD8(+) T cells in tumor immune surveillance and indicate proto-oncogene proteins c-akt (Akt) as a key signaling node in the development of protective memory CD8(+) T-cell responses. | None |
| Data indicate three biomarkers mitogen-activated protein kinase 3 (MAPK3), BCL2 apoptosis regulator (BCL2) and proto-oncogene c-Akt (AKT1) as potential predictors of neurological outcome following cardiac arrest (CA). | None |
| Data suggest Klotho attenuates ox-LDL- (oxidized low density lipoprotein)-induced oxidative stress in vascular endothelial cells via up-regulation of oxidative scavengers (lipoprotein and nitric oxide), activation of the PI3K/Akt/eNOS signaling, and down-regulation of LOX1 (lectin-like ox-LDL receptor) expression. (PI3K = phosphatidylinositol 3-Kinase; Akt = proto-oncogene c-Akt; eNOS = endothelial nitric oxide synthase) | None |