| PEA3, by its capacity to up-regulate the epithelial marker MUC4 and to down-regulate the ErbB-2 oncogene, appears as a key regulator of the differentiation/proliferation balance in pancreatic cancer cells. | pancreatic, |
| Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene. | skin, |
| Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction. | breast, |
| Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition. | prostate, |
| oncogenic Etv4 promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered model of highly penetrant, metastatic prostate cancer | prostate, |
| Data suggested an oncogenic function of ETV4 in pancreatic cancer by demonstrating its increased expression level and its role in growth and cell-cycle progression of pancreatic cancer cells. ETV4-induced cell growth was facilitated by rapid transition of cells from G1- to S-phase of the cell cycle. Mechanistic studies revealed that ETV4 directly regulates the expression of CCND1. | pancreatic, |
| MMP13 potentiates the effects of the ETV4 oncogene during breast cancer genesis and progression. | breast, |
| ETV4 regulates MSI2 transcription by directly at the promoter region. ETV4 exerts oncogenic roles via regulating MSI2 in lung adenocarcinoma. | lung, |
| Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. | None |
| Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. | None |
| The PEA3 protein of the Ets oncogene family is a putative transcriptional modulator of the mouse epididymis-specific glutathione peroxidase gene gpx5. | None |