| The result of this study suggests that FHIT gene may be a tumor suppressor gene in human lung cancer cells. | lung, |
| FHIT gene is one of the chromosome 3p putative tumor suppressor genes involved in the pathogenesis of this highly malignant neoplasm, gallbladder carcinoma | neoplasm,bladder, |
| FHIT tumor suppressor gene is down regulated in prostate carcinoma and may be a potential target for therapeutic intervention | prostate, |
| Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma. | esophageal, |
| Findings suggest that the tumor suppressor gene FHIT may represent a molecular target in cigarette smoking-associated cervical carcinogenesis. | cervical, |
| The high frequency of methylation of the FHIT gene promoter suggests that the inactivation of tumor suppressor genes and of the genes related to the control of cellular proliferation through this mechanism is involved in gallbladder carcinogenesis. | bladder, |
| Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. | lung, |
| Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer. | cervical, |
| Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients. | gastric, |
| Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. | gastric, |
| Using the Affymetrix 6.0 SNP array, the study shows that tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma cell lines. | lymphoma, |
| Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines. | lymphoma, |
| overexpression of Fhit, a tumor suppressor protein, induces autophagy in NSCLC cells. Further, we found that this autophagy is mediated by 14-3-3tau and plays a cytoprotective role against the antitumor effect of Fhit both in vitro and in vivo. | lung, |
| Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair | colorectal, |
| FHIT is missing in most human cancers, indicating it has a tumor suppressor function. Inactivation of only one allele compromises this function, indicating a one-hit mechanism of tumorigenesis is operative. | None |
| exogenous expression of FHIT in Panc-1 cells affects genes regulating cell cycle arrest and apoptosis, and these molecular changes may contribute to the tumor suppressor activity of the FHIT gene | None |
| diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit is inhibited by Ubc9 | None |
| tumour suppressor properties of Fhit are strictly related to its expression level | None |
| The decreases in the values of K(m) and k(cat) for the phosphorylated forms in comparison to those of unphosphorylated Fhit favor the formation and lifetime of the Fhit-Ap(3)A complex, which may enhance the tumor suppressor activity of Fhit. | None |
| FHIT methylation was accumulated through the disease progression of MDS and AML, and the role of the FHIT gene as a tumor suppressor seemed different in AML and MDS | None |