| Diadenosine triphosphatase was isolated from platelets and leukocytes and was identified with the novel tumour suppressor Fhit protein by biochemical and immunochemical evidence. | None |
| Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies. | None |
| Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy. | None |
| absence or poor expression of the Fhit protein in anal cancers suggests a role for this tumor suppressor gene product, as a risk factor, in the onset of this cancer, as reported before for other gastrointestinal tumors | None |
| These observations assign to the tumor suppressor Fhit an unexpected role in the regulation of beta-catenin-mediated gene transcription. | None |
| substrate binding, interaction with heat shock proteins, mitochondrial localization, and interaction with Fdxr are important for Fhit tumor suppressor function | None |
| Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit. | None |
| Nit1 and Fhit tumor suppressor activities are additive. | None |
| Aberrant methylation of tumor suppressor genes in patients with refractory anemia with ring sideroblasts. | None |
| Consistent with the tumor suppressive function of Fhit, the observations in this study suggest that the formation of Galphaq/Fhit complex may modulate cell proliferation. | None |
| The Fhit possesses diadenosine triphosphate hydrolase activity, but although reduction of its enzymatic activity appears to be important for exerting its tumor suppressor function, the regulation of Fhit activity is poorly understood. | None |
| Association of activated G?q to the tumor suppressor Fhit is enhanced by phospholipase C? | None |
| The results have implications for the mechanism by which Fhit regulates TK1 mRNA, and more broadly, for its modulation of multiple functions as tumor suppressor/genome caretaker. | None |
| Small-Molecule Inhibitors of the Tumor Suppressor Fhit | None |
| Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines. | None |
| MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family. | None |