| These FOXF1 alterations are loss-of-function and lead to loss of STAT3-FOXF1 protein interactions and reduced chromatin binding. | lung |
| Enforced FOXF1 expression decreased HCC cell stemness, and the downregulation of FOXF1 promoted cancer cell stemness. The in vivo study showed that overexpressed FOXF1 inhibits nude mouse tumorigenicity with downregulation of CD44 and proliferating cell nuclear antigen. More importantly, loss of FOXF1 expression was linked to poor overall survival time by Kaplan-Meier analysis. | liver |
| FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. | rhabdomyosarcoma |
| a novel cascade mediated by AP-1 and FOXF1 that regulates oncogene-induced senescence, is reported. | unknown |
| FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. | rhabdomyosarcoma |
| FOXF1 behaved not only as a reprogramming regulator that mediates stemness but also as a putative tumor suppressor that contributes to p21-regulated growth suppression during fusion process | unknown |
| Highly Expressed FOXF1 Inhibit Non-Small-Cell Lung Cancer Growth via Inducing Tumor Suppressor and G1-Phase Cell-Cycle Arrest. | lung |