| DKK-1 expression decreases in human colon tumors, suggesting that DKK-1 acts as a tumor suppressor gene in this neoplasia; the Wnt/beta-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer | colorectal, |
| Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. | kidney, |
| HOTTIP regulates colorectal cancer cell metastasis partly through the downregulation of tumor suppressor DKK1 expression | colorectal, |
| Together, our data suggest that Dkk-1 may be able to antagonize Wnt signaling and exert its tumor suppressive effects through beta-catenin-independent non-canonical pathways (i.e., the Wnt/JNK pathway). | None |
| Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. | None |
| DKK-1 mediated tumor suppressor effect is independent of beta-catenin dependent transcription and a CamKII pathway contributes to DKK-1 signaling | None |
| Study confirmed that decreased DKK1 in trophoblast tumor cell lines was related to promoter hypermethylation and showed that DKK1 was a tumor suppressor gene through wnt signaling pathway regulation. | None |
| The Paradox of Dickkopf-1: Tumor Suppressor and Tumor Enhancer | None |
| The Dickkopf-1 (DKK1) is a secreted inhibitor of beta-catenin-dependent Wnt signalling and was originally characterized as a tumour suppressor based on the prevailing view that Wnt signalling promotes cancer pathogenesis. | None |
| Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. | lung, |