| AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways. | neuroblastoma,liver,thymoma, |
| Findings defined Cav-1 as an important downstream oncogenic target of FoxM1, suggesting that dysregulated signaling of this novel FoxM1-Cav-1 pathway promotes pancreatic cancer development and progression. | pancreatic, |
| we found that the downregulation of ETV5 reduced the expression of the oncogenic transcription factor FOXM1. Consistently, FOXM1 was overexpressed in ovarian tumor samples, and its transcriptional levels increased with ETV5 transcription | ovarian, |
| FOXM1 is an oncogenic mediator in Ewing Sarcoma. | sarcoma, |
| FOXM1 is an oncogenic mediator in Ewing Sarcoma. | sarcoma, |
| FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis. | pancreatic, |
| SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. | prostate, |
| SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. | prostate, |
| FOXM1 and its Oncogenic Signaling in Gastric Cancer. | gastric, |
| review of role in oncogenic signaling in gastric cancer | gastric, |
| FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer. | ovarian, |
| our study provide convincing evidences that FoxM1-regulated PBK exerts oncogenic activities towards HCC via the activation of beta-Catenin pathway. | liver, |
| Transcriptome analyses and knockdown experiments revealed a major role for FOXM1 in this response. CDK4/6 inhibition resulted in reduced FOXM1 phosphorylation in vitro and in vivo and showed synergy with CDDP, allowing a significant tumor regression. FOXM1 exerted important oncogenic roles in bladder cancer | bladder, |
| Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1. | None |
| Induction of Foxm1 by oncogenic Ras requires reactive oxygen species (ROS). Elevated Foxm1, in turn, downregulates ROS levels by stimulating expression of ROS scavenger genes. | None |
| In vivo suppression of the oncogenic FOXM1 after treatment with proteasome inhibitors. | None |
| The oncogenic transcription factor FOXM1 and anticancer therapy. | None |
| The oncogenic potential of FOXM1 is mainly based on its ability to transcriptionally activate genes that are involved in different facets of cancer development | None |
| FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy. | None |
| Up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is required for human papillomavirus-associated tumorigenesis. | None |