| Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. | neoplasm, |
| In prostate cancer, FOXO3a, and YB-1 play inverse reciprocal roles as a tumor-suppressor gene and oncogene, respectively, regulated by ERK signaling. | prostate, |
| Identification of the tumor?suppressive function of circular RNA FOXO3 in non?small cell lung cancer through sponging miR?155 | lung, |
| The tumor suppressor FOXO3a mediates the response to EGFR inhibition in glioblastoma cells | glioblastoma, |
| Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. | None |
| Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. | None |
| FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. | None |
| Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model. | None |
| Results show that a new mechanism of oncogenesis is attributed to p68 by upregulation of AKT and consequent nuclear exclusion and degradation of tumor suppressor FOXO3a. | None |
| PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor | None |
| O-GlcNAcylation of the Tumor Suppressor FOXO3 Triggers Aberrant Cancer Cell Growth | None |
| Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer. [review] | None |