| PDGFC was identified as target of EWS/ETS transcriptionalderegulation specific to EWS/FLI-1 chimeras in the Ewing Family Tumors suggesting that it may be a significant mediator of EWS/FLI driven oncogenesis. | None |
| Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein. | None |
| FLI1 interacts with EWS and their oncogenic fusion protein. | None |
| Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein. | None |
| Recombinant EWS-FLI1 oncoprotein activates transcription. | None |
| Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. | None |
| GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. | None |
| Results suggest that the oncogenicity of Spi-1, Fli-1, and possibly other ETS transcription factors may involve their ability to stimulate ribosome biogenesis. | None |
| The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. | None |
| EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo. | None |
| Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. | None |
| Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening. | None |
| Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors. | None |
| Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. | None |
| Results show that EWSR1/FLI1 binding independent of E2F3 is predominantly associated with repressed differentiation genes. Thus, EWSR1/FLI1 appears to promote oncogenesis by simultaneously promoting cell proliferation and perturbing differentiation. | None |
| EWS-FLI1 establishes an oncogenic regulatory program governing both tumor survival and differentiation. | None |
| RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1. | None |
| Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. | None |
| Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. | None |
| Fusion of short fragments of EWSR1 to FLI1 is sufficient to recapitulate BAF complex retargeting and EWS-FLI1 activities; studies thus demonstrate that the physical properties of prion-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs. | None |