| study identified a novel heterozygous missense germline mutation in DICER1 cancer predisposition gene segregating with familial Hodgkin lymphoma (HL); showed significant down-regulation of tumor suppressor miRNAs in DICER1-mutated family members, suggesting this mechanism might trigger development of HL in this family | lymphoma, |
| Dicer1 may be an important haploinsufficient tumor suppressor gene | None |
| We conclude that Dicer1 functions as a haploinsufficient tumor suppressor. This finding has implications for cancer etiology and cancer therapy. | None |
| The results suggest that mutation of the clinically relevant residue D1709 in the RNase IIIB results in a uniquely miRNA-haploinsufficient state in which the let-7 family of tumor suppressor miRNAs is lost while a complement of 3p-derived miRNAs remains. | None |
| Dicer functions as an indirect tumor suppressor, as silencing Dicer expression makes cancer cells more malignant. | None |
| [DICER1: A new model of epigenetic tumor suppressor gene] | None |
| Data indicate that Dicer1 can function as a traditional loss-of-function tumor suppressor gene. | None |
| data confirm DICER1 as a tumor suppressor and show that oncogenic miR-146b contributes to its downregulation | None |