| these results highlight the tumor-suppressive role of SIRT4 in Myc-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc-induced and/or glutamine-dependent cancers. | lymphoma, |
| SIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion | gastric, |
| Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage | neuroblastoma, |
| Mammalian SIRT4 is a tumor suppressor of clear cell renal cell carcinoma by inhibiting cancer proliferation, migration and invasion | kidney, |
| Data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine metabolism, cell cycle arrest, and tumor suppression. | None |
| SIRT4 behaves as a tumor suppressor at the human tissue protein level. | None |
| Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer | None |