| Coexpression of activated ALK with MYCN provides prosurvival signals that block this apoptotic response and allow continued expansion and oncogenic transformation of hyperplastic neuroblasts, thus promoting progression to neuroblastoma. | neuroblastoma, |
| Expression of MYCN or ALK(F1174L), one of the oncogenic ALK variants identified in primary neuroblastomas, enabled these cells to grow independently of c-MycER(T) activity in vitro and caused formation of neuroblastoma-like tumors. | neuroblastoma, |
| The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. | lymphoma, |
| A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer. | lung, |
| Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. | lung, |
| Sensitive detection of EML4-ALK fusion oncoprotein of lung cancer by in situ proximity ligation assay. | lung, |
| The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. | neuroblastoma, |
| The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. | neuroblastoma, |
| Development of lung adenocarcinomas with exclusive dependence on oncogene fusions. | lung, |
| Induction of PD-L1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer. | lung, |
| ALK oncogenic activity is involved in the regulation of an epithelial mesenchymal transition phenotype in a subset of non-small cell lung carcinomas by repression of the epithelial splicing regulatory protein 1. | lung, |
| Studies showed recurrent oncogenic alterations suche as chromosomal translocation and gene amplification of ALK in anaplastic large-cell lymphoma, inflammatory myofibroblastic tumor, and neuroblastoma and has highlighted the importance for ALK in histologically diverse pediatric cancers. [review] | lymphoma,neuroblastoma,pediatric, |
| Novel oncogenic ALK fusion transcripts have been found in non-small cell lung cancer patients using next-generation sequencing approaches. | lung, |
| The EML4-ALK fusion gene may be a strong oncogene in younger patients with lung adenocarcinoma. | lung, |
| Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). | lymphoma, |
| Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis. | None |
| results show a pivotal role for Bcl-XL in ALK-mediated oncogenicity | None |
| ALK has roles in oncogenesis of haematopoietic and non-haematopoietic tumors [review] | None |
| can be adapted for the identification of known and unknown translocation partners of chimeric ALK fusion proteins involved in oncogenesis | None |
| A liaison dangereuse between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK. | None |