| Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. | neoplasm,breast, |
| Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. | lung, |
| Activated BRK-mediated degradation of SMAD4 is associated with the repression of tumor suppressor gene FRK. | None |
| FRK plays an oncogenic role in lung cancer cells via a novel regulation mechanism of enhancing the stemness of H1299 cells by inducing metabolism reprogramming, which finally promotes epithelial-mesenchymal transition and metastasis | lung, |