| Mice with human 15-LOX-1 expression in colonic epithelial cells were less susceptible than wild-type mice to AOM-induced colonic tumorigenesis. 15-LOX-1 appears to act as a tumor suppressor and an inhibitor of TNF-alpha-iNOS signaling and NF-kappaB activation. | colorectal, |
| The 15-LOX-1 protein binds to DNA-PK, increasing its kinase activity and results in downstream activation of the tumor suppressor p53, thus revealing a new mechanism by which lipoxygenases (LOX) may influence the phenotype of tumor cells. | None |
| 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma | None |