| MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer. | esophageal, |
| LATS2 is a tumor suppressor gene of malignant mesothelioma. | mesothelioma, |
| Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. | breast,prostate, |
| The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation | liver, |
| Co-occurring Mutations of Tumor Suppressor Genes, LATS2 and NF2, in Malignant Pleural Mesothelioma | mesothelioma, |
| LATS2 is a tumor suppressor of lung cancer via triggering mitochondrial fission and activation of the JNK-Mff signaling pathway. | lung, |
| Study revealed that LATS2 was downregulated in glioma tissues and cells. Overexpression of LATS2 in glioblastoma cells inhibited cell proliferation, migration and invasion. Expression levels of phosphorylated YAP and tafazzin were increased in cells with LATS2 overexpression. These results indicated that LATS2 is a potential tumor suppressor, and downregulation of LATS2 in glioma may contribute to cancer progression. | glioblastoma,glioma, |
| Data show NF-kappa-B (NFkappaB) is required to initiate pancreatic epithelial-mesenchymal transition (EMT) downstream of large tumor suppressor kinases 1 and 2 (Lats1/2) deletion. | pancreatic, |
| Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. | None |
| Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. | None |
| Lats2, a putative tumor suppressor, inhibits G1/S transition. | None |
| The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. | None |
| Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). | None |
| The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. | None |
| Tumor suppressor LATS1 is a negative regulator of oncogene YAP. | None |
| Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. | None |
| LATS2 tumor suppressor gene is regulated by tristetraprolin | None |
| The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. | None |
| KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif | None |
| Results reveal a functional connection between the pRB and Hippo tumor suppressor pathways, and suggest that low levels of LATS2 may undermine the ability of pRB to induce a permanent cell cycle arrest in tumor cells. | None |