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Cancertype
Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve
ovarian,
HBP1 functions as a non-tumor suppressor gene in nasopharyngeal carcinoma.
nasopharyngeal,laryngeal,
HBP1 functions as a tumor suppressor, and its ectopic expression hindered cell proliferation of non-small-cell lung cancer (NSCLC). AFAP1-AS1 repressed HBP1 expression by recruiting LSD1 to the HBP1 promoter regions in NSCLC cell lines.
lung,
in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation
None
The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.
None
results suggest that HBP1 phosphorylation by AKT blocks its functions as transcriptional regulator and tumor suppressor.
None