| Aberrant methylation of the DKK3 promoter downregulates mRNA & protein expression in human breast cancer development. It may be a tumor suppressor in normal breast tissue. | breast, |
| data demonstrate that MYCN-regulated miRNAs are able to modulate the expression of the tumor suppressor DKK3 in neuroblastoma | neuroblastoma, |
| Results implicate Dickkopf3 as a tumor suppressor in human pancreatic cancer, through the downregulation of beta-catenin expression via the ERK-mediated pathway. | pancreatic, |
| Dkk3 gene expression is frequently downregulated in endometrial cancer, and is associated with poor prognostic clinicopathologic markers. Results identify a role for Dkk3 as a tumor suppressor in EC, affecting both proliferation and invasiveness. | endometrial, |
| DKK3 gene is a potential tumor suppressor gene in thyroid cancer, and aberrant promoter methylation is an important mechanism for its downregulation, which may play a role in the tumorigenesis and aggressiveness of papillary thyroid carcinoma. | thyroid, |
| The Downregulation of the Expression of CD147 by Tumor Suppressor REIC/Dkk-3, and Its Implication in Human Prostate Cancer Cell Growth Inhibition | prostate, |
| Tumor necrosis factor-? downregulates the REIC/Dkk-3 tumor suppressor gene in normal human skin keratinocytes | skin, |
| Dickkopf Homolog 3 (DKK3) Acts as a Potential Tumor Suppressor in Gallbladder Cancer | bladder, |
| Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1. | None |
| Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity | None |
| dickkopf-3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers. | None |
| Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3_-side of the transgene | None |
| Tumor suppressor REIC/Dkk-3 and its interacting protein SGTA inhibit glucocorticoid receptor to nuclear transport | None |
| These data demonstrated that Dkk-3 expression in OSCC was different than that in adenocarcinomas. Dkk-3 may possess an oncogenic function that is independent of Wnt signaling. | None |