| data suggest that PDCD4 is a proapoptotic molecule involved in TGF-beta1-induced apoptosis in human HCC cells, and a possible tumor suppressor in hepatocarcinogenesis | liver, |
| Downregulation of tumor suppressor Pdcd4 promotes colonic neoplastic transformation and tumor invasion | colorectal, |
| MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. | glioblastoma, |
| 13-HOA (40 muM and 1600 nmol in JB6 cells and mouse skin, respectively) induced expression of programmed cell death 4 (Pdcd4), a novel tumor suppressor protein | skin, |
| Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. | breast, |
| Identified up-regulation of microRNA-21 (hsa-miR-21) concurrent with down-regulation of potent tumor suppressor proteins PTEN and programmed cell death 4 in cholesteatoma as compared with normal skin. | skin, |
| miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation, and up-regulated the expression of the tumor suppressor gene PDCD4. | cervical, |
| Data provide evidence that the tumor suppressor, programmed cell death factor 4 (PDCD4), is a previously unidentified phosphorylation target of CXCL12 signaling in all Chronic Lymphocytic Leukemia cells probed. | leukemia, |
| Tumor suppressor Pdcd4 is a major transcript that is upregulated during in vivo pancreatic islet neogenesis and is expressed in both beta-cell and ductal cell lines. | pancreatic, |
| PDCD4 gene is anti-oncogene that may play an important role in the pathogenesis and development of laryngeal carcinoma. | laryngeal, |
| Expression patterns of the tumor suppressor PDCD4 and correlation with ??-catenin expression in gastric cancers. | gastric, |
| Suppression of tumor suppressor PDCD4 expression may be one of the important regulatory pathways of miR-21-mediated cell proliferation and decrease of apoptosis in non-small cell lung cancer. | lung, |
| Data indicate that berberine could inhibit miR-21 expression and function in ovarian cancer by an enhancement of its target PDCD4, an important tumor suppressor in ovarian cancer. | ovarian, |
| miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 | gastric, |
| Results show that miR-21 was overexpressed in all tested head and neck squamous carcinoma cell lines, and regulated cellular proliferation possibly through downregulation of the tumor suppressor PDCD4. | HNSC, |
| we demonstrate that miR-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4. | leukemia, |
| miR-21 can confer drug resistance to 5-FU in pancreatic cancer cells by regulating the expression of tumor suppressor genes, as the target genes of miR-21, PTEN and PDCD4 can rescue 5-FU sensitivity and the phenotypic characteristics disrupted by miR-21. | pancreatic, |
| Results indicated that PDCD4 may be a novel candidate of tumor suppressor gene in hepatocellular carcinoma and that promoter hypermethylation is an important mechanism for its downregulation and a good predictor of survival. | liver, |
| Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma | colorectal, |
| Various studies support evidence that PDCD4, is a novel tumor suppressor gene, and is downregulated or even absent in colorectal cancer (CRC) and suppresses CRC deterioration. [review] | colorectal, |