| PDCD4-AS1 lncRNA positively regulates the expression and activity of the tumor suppressor PDCD4 in mammary epithelial cells. Both PDCD4-AS1 and PDCD4 show reduced expression in triple negative breast cancer cell lines and in patients, and depletion of PDCD4-AS1 compromised the cellular levels and activity of PDCD4. | breast, |
| PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance | prostate, |
| Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. | None |
| Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. | None |
| Structural basis for inhibition of translation by the tumor suppressor Pdcd4. | None |
| Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. | None |
| we conclude that the function of Pdcd4 might be cell type specific. A role for Pdcd4 in apoptosis or as a tumor suppressor might be limited to certain cell types. | None |
| mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4 | None |
| The tumor suppressors PTEN and PDCD4 are downregulated by RAS in an AP-1- and miR-21-dependent fashion.(mir-21) | None |
| Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. | None |
| Regulation of tumor suppressor PDCD4 by novel protein kinase C isoforms. | None |
| Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor. | None |
| results reveal a new cofactor for PDCD4 that alters its tumor suppressor functions and point to the utility of PDCD4/PRMT5 status as both a prognostic biomarker and a potential target for chemotherapy | None |
| PDCD4 is down-regulated in human RCC, which is correlated with biological aggressiveness and poor prognosis. As a tumor suppressor, PDCD4 probably plays an important role during the tumorigenesis of RCC. | None |
| PDCD4 as a specific repressor of the internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2 dependent translation of cellular mRNAs (such as XIAP and Bcl-x(L)) that mediate FGF-2-S6K2 prosurvival signaling and provide further insight into the role of PDCD4 in tumor suppression | None |
| PDCD4 as tumor suppressor regulated miR-184-mediated direct targeting of BCL2 and C-MYC. | None |
| increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4. | None |
| RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4 | None |
| Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4 | None |
| Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor. | None |