| gain- and loss-of-function studies identify a previously unrecognized tumor suppressor function for Galphas that can be found consistently across Shh-group medulloblastomas of disparate cellular and anatomical origins | medulloblastomas, |
| This study highlights an important tumour suppressive function of Galphas-PKA, limiting the proliferation of epithelial stem cells and maintaining proper hair follicle homeostasis. | None |
| Conditional overexpression of the wild-type Gs alpha as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines. | pituitary, |
| Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. | pituitary, |
| Activating point mutations of the gsp oncogene in human thyroid adenomas. | thyroid, |
| A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours. | pituitary, |
| An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro. | thyroid, |
| Impact of gsp oncogene on the expression of genes coding for Gsalpha, Pit-1, Gi2alpha, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity. | None |
| Effect of gsp oncogene on somatostatin receptor subtype 1 and 2 mRNA levels in GHRH-responsive GH3 cells. | None |
| data suggest that higher expression of somatostatin receptor subtype 1 and 2 mRNA induced by the gsp oncogene may be a mechanism by which gsp-positive tumors show a greater response to somatostatin | None |
| Overexpression of the wild-type G(s)alpha protein as the gsp oncogene initiated chronic activation of endogenous prolactin synthesis and release, as well as chronic activation of ERK1/2-sensitive human prolactin and GH promoters. | None |
| Impact of gsp oncogene on the mRNA content for somatostatin and dopamine receptors in human somatotropinomas. | None |
| The oncogenic Galphas mutation R201C allows GDP-bound Galphas to activate adenylyl cyclase. | None |