| Study found that H19 is downregulated in papillary thyroid carcinoma (PTC), and is associated with lymph node metastasis. H19 inhibits the proliferation and migration of PTC cells. Since H19 inhibits TNFR2 expression, there is a possibility that H19 may function as a tumor suppressor by negatively regulating TNFR2 in PTC. | thyroid, |
| The H19 locus acts in vivo as a tumor suppressor. | None |
| In this review, author summarized the gene as tumor suppressor in table 2. | None |
| Tumour-suppressor activity of H19 RNA. | None |
| An overload of H19 transcript is associated with cells exhibiting higher tumorigenic phenotypes and therefore the H19 gene has oncogenic properties in breast epithelial cells. | breast, |
| Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells. | breast, |
| Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. | gastric, |
| Histone h1.3 suppresses h19 noncoding RNA expression and cell growth of ovarian cancer cells. | ovarian, |
| H19 is upregulated in esophageal squamous cell carcinoma (ESCC). Findings indicate that H19 acts as an oncogene and promotes ESCC cell proliferation and metastasis. | esophageal, |
| Long non-coding RNA H19 was found to play an oncogenic role in oral squamous cell carcinoma cells by regulating EZH2 and by targeting miR138. | oral |
| LncRNA-H19 has an oncogenic role in retinoblastoma tumor cells via regulation of the miR-143 and RUNX2 axis. | retinoblastoma, |
| H19 is a promising prognostic factor in Pancreatic neuroendocrine neoplasms (pNENs) with malignant behaviors and functions as an oncogene via the VGF-mediated PI3K/AKT/CREB pathway. In addition, our study implies that VGF may also serve as a candidate prognostic biomarker and therapeutic target in pNENs. | pancreatic,neoplasm, |
| the oncogenic properties of H19 in nasopharyngeal carcinoma | nasopharyngeal,laryngeal, |
| H19 RNA harbors pro-tumorigenic properties, thus the H19 gene behaves as an oncogene and may serve as a potential new target for anti-tumor therapy | None |
| The H19 non-coding RNA is essential for human tumor growth. | None |
| Report shows that H19 promotes tumor cell migration and invasion by inhibiting let-7 functions to post-transcriptionally suppress the expression of oncogenes that regulate cell growth and motility. | None |
| Our results suggest that H19 oncogenicity in human embryonic carcinoma cells is mediated through the regulation of the pluripotency state. | None |
| H19 is overexpressed and plays oncogenic role in PDAC through promoting cancer cell proliferation via the upregulation of E2F-1. | None |